TECHNOLOGICAL WATCH SERVICE
Technical Article
Powered by:

In vitro assessment of Ag-TiO2/polyurethane nanocomposites for infection control using response surface methodology

Combining the use of a central composite design (CCD) with a response surface methodology (RSM), Ag-TiO2/Polyurethane (PU) nanocomposites with superior antimicrobial activities and minimal color changes were developed and optimized for self-disinfecting coating. An experimental design was utilized to assess the effects of two independent variables: 1) AgNO3 content and 2) TiO2 content on four measured responses, i.e., the reduction of E. coli and S. aureus, color differences, and the amount of Ag+ release of nanocomposites. The nanocomposites were characterized by Transmission Electron Microscope, and X-ray diffraction. To validate the optimal conditions for real clinical applications for Ramathibodi Hospital (Bangkok, Thailand), the performance evaluations of the coatings such as cytotoxicity test and color differences were conducted, and the antibacterial activities were tested against seven key strains of antibiotic-resistant bacteria. The result suggested that this formulation has high potential for self-disinfecting coating applications.

» Author: Phasinee Khwanmuang, Porpon Rotjanapan, Angsana Phuphuakrat, Sirawat Srichatrapimuk, Chayanisa Chitichotpanya

» Reference: Reactive and Functional Polymers

» More Information

« Go to Technological Watch



AIMPLAS - Instituto Tecnológico del Plástico | C/ Gustave Eiffel, 4 (Valčncia Parc Tecnolňgic) | 46980 - PATERNA (Valencia) - SPAIN
(+34) 96 136 60 40
ecogelcronos@aimplas.es

This project has received funding from the European Union Seventh Framework Programme (FP7/2007-2013) under grant agreement n° [609203].

The sole responsibility for the content of this website lies with the authors. It does not necessarily reflect the opinion of the EC. The EC is not responsible for any use that may be made of the information contained therein.